In a large bowl, combine crab meat, panko breadcrumbs, chopped onion, minced garlic, mayonnaise, beaten egg, and Dijon mustard or Worcestershire sauce.
Season the mixture with salt and pepper and gently mix until just combined, keeping the texture light.
Shape the crab mixture into small bite-sized balls or patties.
Press each bite into additional panko or breadcrumbs to evenly coat.
Heat oil in a skillet to about ½ inch deep over medium-high heat until shimmering.
Fry crab bites in batches until golden brown on all sides, about 2–3 minutes per side.
Remove bites with a slotted spoon and drain on paper towels to remove excess oil.
Serve warm with lemon wedges, tartar sauce, or your favorite dipping sauce.